In contrast to genes in bacteria, eukaryotic genes are split by non-coding sequences called introns. In eukaryotes, as a gene is transcribed from DNA into a 展开

Exon scrambling
Exon scrambling, also called exon shuffling, describes an event in which exons are spliced in a "non-canonical" (atypical) order. There are … 展开

Repetitive Alu sequences represent approximately 10% of the human genome. The presence of Alu elements in flanking introns of protein-coding … 展开

Early discoveries of circRNAs
Early discoveries of circular RNAs led to the belief that they lacked significance due to their rarity. These early discoveries included the analysis of … 展开

Alternative splicing is a phenomenon through which one RNA transcript can yield different protein products based on which segments are considered "introns" and "exons" during a splicing event. Although not specific to humans, it is a partial explanation for … 展开

RNAs can undergo base modification by RNA editing after transcription. RNA editing occurs mainly in Alu elements of protein-coding genes. A-to … 展开

Evolutionary conservation of circularization mechanisms and signals
CircRNAs have been identified in various species across the domains of life. In 2011, Danan et al. sequenced RNA from Archaea. After digesting total RNA with RNase R, they were able … 展开