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  1. Protein-protein interactions are associated with key activities and pathways in the cell, and in that regard are promising targets for drug discovery. However, in terms of small molecule drugs, this promise has not been realized.

    Targeting protein-protein interactions for drug discovery

    pubmed.ncbi.nlm.nih.gov/25859945/
    pubmed.ncbi.nlm.nih.gov/25859945/
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  2. 其他用户还问了以下问题
    Why is protein-protein interaction important in drug discovery?
    Small molecules, big targets: drug discovery faces the protein-protein interaction challenge Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states.

    Small molecules, big targets: drug discovery faces the protein-protein in…

    pubmed.ncbi.nlm.nih.gov
    How can protein complexes be used for drug discovery?
    Protein complexes can also be involved in the development of pathologies and searching for inhibitors of the protein–protein interactions (PPIs) is a promising field for drug discovery. Strategies for the development of PPIs inhibitors can be based on its direct interaction with the binding interface of the partner proteins.

    Protein–Protein Interaction for Drug Discovery - Springer

    link.springer.com
    Are protein-protein interactions a target class for drug discovery?
    Protein–protein interactions (PPIs) are increasingly being targeted by drug discovery groups, and there exists great scope for therapeutic modulation of this target class in disease. The array of structurally interacting elements through which proteins interact with one another is wide and resists clear-cut classification.

    Small molecules, big targets: drug discovery faces the protein ... - Na…

    nature.com
    How do proteins play a role in drug discovery and pharmacodynamics?
    Proteins with shared pathway functions can help elucidate mechanism of drug action (e.g., up/down regulation) and play roles in drug discovery, biomarker discovery and pharmacodynamics (PD) [26, 30]. Protein dynamics can be well-characterized by measuring the rates of biomolecular synthesis and degradation.

    Protein–Protein Interaction for Drug Discovery - Springer

    link.springer.com
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  3. Nature
    https://www.nature.com/articles/s41392-020-00315-3翻译

    Recent advances in the development of protein–protein …

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  4. EMBO Press
    https://www.embopress.org/doi/full…翻译

    AI-guided pipeline for protein–protein interaction drug …

    网页2024年3月11日 · A new pipeline for prioritizing protein-protein interactions (PPIs) for drug discovery, combines machine learning-based scoring of quantitative PPI data, protein complex structure prediction and vi...

  6. Nature
    https://www.nature.com/articles/nrd.2016.29翻译

    Small molecules, big targets: drug discovery faces the …

  7. Springer
    https://link.springer.com/chapter/10.1007/978-3...翻译

    Protein–Protein Interaction for Drug Discovery | SpringerLink

    标记:
    Protein–protein interaction
    Springer Science+Business Media
  8. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/...翻译

    Drug discovery by targeting the protein–protein interactions …

  9. Nature
    https://www.nature.com/articles/s42256-020-0152-y翻译

    Predicting drug–protein interaction using quasi-visual question ...

    标记:
    Protein–protein interaction
    Publish Year:2020
  10. Frontiers
    https://www.frontiersin.org/journals/chemistry...翻译

    Editorial: Protein–Protein Interactions: Drug Discovery for the Future

  11. Cell Press
    https://www.cell.com/cell-genomics/fulltext/S2666...翻译

    Identifying compound-protein interactions with knowledge graph ...

    标记:
    Protein–protein interaction
    Graph embedding
  12. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/...翻译

    Multi-level bioinformatics resources support drug target discovery …

    标记:
    Protein–protein interaction
    Protein Protein Interaction
  13. PubMed
    https://pubmed.ncbi.nlm.nih.gov/27050677翻译

    Small molecules, big targets: drug discovery faces the protein …

    标记:
    Small Molecules
    Development