Dissociative Anesthetics | SpringerLink
Learn about the definition, history, pharmacological properties, and mechanisms of action of dissociative anesthetics, such as ketamine, nitrous oxide, and dextromethorphan. Find out how these agents produce catalepsy, analgesia, amnesia, and other effects by interfering with sensory and cognitive processing. 展开
Most dissociative anesthetics are members of the phenyl cyclohexamine group of chemicals. Agents from this group were first used in clinical practice in the 1950s. Early … 展开
For medical use, a 10 or 50 mg/mL solution is administered by intramuscular injection or, more commonly, by intravenous injection. Being a lipophilic drug, the onset of clinical … 展开
The primary direct molecular mechanism of action of ketamine (in common with other dissociative agents such as nitrous oxide, phencyclidine, and dextromethorphan) occurs via a noncompetitive antagonist effect at the N-methyl-d-aspartate … 展开
Ketamine is used in clinical practice in two main indications. At moderate doses, it is a powerful analgesic, whereas at higher doses it is used as an anesthetic agent in specific situations (see below). Its ability to block NMDA receptors has prompted studies investigating its … 展开
The multiple faces of ketamine in anaesthesia and analgesia
网页2020年12月8日 · Ketamine is an anaesthetic agent with a unique dissociative profile and pharmacological effects ranging from the induction and maintenance of anaesthesia to …
- 作者: Silvia Natoli
- DOI: 10.7573/dic.2020-12-8
- Publish Year: 2021
- Publication: Drugs Context. 2021; 10: 2020-12-8.
Ketamine: 50 Years of Modulating the Mind - PMC | National …
网页2016年11月29日 · Ketamine produces an unusual state, sometimes referred to as “dissociative anesthesia”, which was a term coined by Domino’s wife. During this …
- 作者: Linda Li, Phillip E. Vlisides
- DOI: 10.3389/fnhum.2016.00612
- Publish Year: 2016
- Publication: Front Hum Neurosci. 2016; 10: 612.
Dissociative Anesthetic Agent - an overview | ScienceDirect
网页Learn about dissociative anesthetic agents, such as PCP, ketamine, and dextromethorphan, that can cause analgesia, anesthesia, and CNS inebriation by …
Ketamine - StatPearls | NCBI Bookshelf
网页2024年1月30日 · Ketamine hydrochloride is a nonbarbiturate dissociative anesthetic. As a cyclohexanone derivative, the drug rapidly acts and produces profound anesthesia and analgesia. Its chemical …
The role of dissociation in ketamine’s antidepressant effects
网页2020年12月22日 · Ketamine is associated with rapid antidepressant effects and temporary dissociative experiences, and this review examines whether these dissociative symptoms …
网页Learn about dissociative anesthesia, a form of anesthesia characterized by catalepsy, catatonia, analgesia, and amnesia. Explore the pharmacological properties, history, …
Dissociative Anesthesia | JAMA Network
网页Learn about dissociative anesthesia, a type of anesthesia that produces catalepsy, amnesia, and analgesia in patients. The article describes the clinical effects, …
Dissociative Anesthetics - Psychopharmacology | Pharmacological …
网页2023年8月6日 · Dissociative anesthesia is a type of anesthetic that produces an altered state of consciousness and is used for surgical, diagnostic, and therapeutic …
Ketamine a dissociative anesthetic: Neurobiology and ... | PubMed
网页2020年3月1日 · Anesthetics, Dissociative. Ketamine. Ketamine is gaining ground as a potential treating depression because it has a distinct mode of action than typical drugs …
